Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1073/pnas.0406798102 |
Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars | |
Skelley, AM; Scherer, JR; Aubrey, AD; Grover, WH; Ivester, RHC; Ehrenfreund, P; Grunthaner, FJ; Bada, JL; Mathies, RA | |
通讯作者 | Mathies, RA |
来源期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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ISSN | 0027-8424 |
出版年 | 2005 |
卷号 | 102期号:4页码:1041-1046 |
英文摘要 | The Mars Organic Analyzer (MOA), a microfabricated capillary electrophoresis (CE) instrument for sensitive amino acid biomarker analysis, has been developed and evaluated. The microdevice consists of a four-wafer sandwich combining glass CE separation channels, microfabricated pneumatic membrane valves and pumps, and a nanoliter fluidic network. The portable MOA instrument integrates high voltage CE power supplies, pneumatic controls, and fluorescence detection optics necessary for field operation. The amino acid concentration sensitivities range from micromolar to 0.1 nM, corresponding to part-per-trillion sensitivity. The MOA was first used in the lab to analyze soil extracts from the Atacama Desert, Chile, detecting amino acids ranging from 10-600 parts per billion. Field tests of the MOA in the Panoche Valley, CA, successfully detected amino acids at 70 parts per trillion to 100 parts per billion in jarosite, a sulfate-rich mineral associated with liquid water that was recently detected on Mars. These results demonstrate the feasibility of using the MOA to perform sensitive in situ amino acid biomarker analysis on soil samples representative of a Mars-like environment. |
英文关键词 | amino acid analysis astrobiology capillary electrophoresis microfabrication |
类型 | Article |
语种 | 英语 |
国家 | USA ; Netherlands |
收录类别 | SCI-E |
WOS记录号 | WOS:000226617900017 |
WOS关键词 | MARTIAN METEORITE ALH84001 ; EXTRATERRESTRIAL EXPLORATION ; ATACAMA DESERT ; LIFE ; SEARCH ; ENANTIOMERS ; BACTERIA ; DEVICES ; SAMPLES ; SOILS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
来源机构 | University of California, Berkeley |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/150240 |
作者单位 | (1)Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA;(2)Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA;(3)Leiden Univ, Astrobiol Lab, NL-2300 RA Leiden, Netherlands;(4)CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA |
推荐引用方式 GB/T 7714 | Skelley, AM,Scherer, JR,Aubrey, AD,et al. Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars[J]. University of California, Berkeley,2005,102(4):1041-1046. |
APA | Skelley, AM.,Scherer, JR.,Aubrey, AD.,Grover, WH.,Ivester, RHC.,...&Mathies, RA.(2005).Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,102(4),1041-1046. |
MLA | Skelley, AM,et al."Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102.4(2005):1041-1046. |
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