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DOI | 10.1038/ncb1213 |
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes | |
Kondo, S; Murakami, T; Tatsumi, K; Ogata, M; Kanemoto, S; Otori, K; Iseki, K; Wanaka, A; Imaizumi, K | |
通讯作者 | Imaizumi, K |
来源期刊 | NATURE CELL BIOLOGY
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ISSN | 1465-7392 |
EISSN | 1476-4679 |
出版年 | 2005 |
卷号 | 7期号:2页码:186-U112 |
英文摘要 | Endoplasmic reticulum (ER) stress transducers IRE1, PERK and ATF6 are well known to transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. Here, we identified OASIS as a novel ER stress transducer. OASIS is a basic leucine zipper ( bZIP) transcription factor of the CREB/ATF family with a transmembrane domain that allows it to associate with the ER. The molecule is cleaved at the membrane in response to ER stress, and its cleaved amino-terminal cytoplasmic domain, which contains the bZIP domain, translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements. Intriguingly, OASIS was induced at the transcriptional level during ER stress in astrocytes of the central nervous system, but not in other cell types examined. Furthermore, overexpression of OASIS resulted in induction of BiP and suppression of ER-stress-induced cell death, whereas knockdown partially reduced BiP levels and led to ER stress in susceptible astrocytes. Our results reveal pivotal roles for OASIS in modulating the unfolded protein response in astrocytes, and the possibility that cell type-specific UPR signalling also exists in other cells. |
类型 | Article |
语种 | 英语 |
国家 | Japan |
收录类别 | SCI-E |
WOS记录号 | WOS:000226719500016 |
WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; TRANSCRIPTION FACTOR ; ER STRESS ; MESSENGER-RNA ; GRP78 ; IDENTIFICATION ; EXPRESSION ; APOPTOSIS ; ELEMENT |
WOS类目 | Cell Biology |
WOS研究方向 | Cell Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/150015 |
作者单位 | (1)Miyazaki Univ, Fac Med, Dept Anat, Miyazaki 8891692, Japan;(2)Nara Inst Sci & Technol NAIST, Div Struct Cellular Biol, Nara 6300101, Japan;(3)Nara Med Univ, Dept Anat, Nara 6348522, Japan;(4)Yamagata Univ, Sch Med, Dept Emergency Med, Yamagata 9909585, Japan |
推荐引用方式 GB/T 7714 | Kondo, S,Murakami, T,Tatsumi, K,et al. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes[J],2005,7(2):186-U112. |
APA | Kondo, S.,Murakami, T.,Tatsumi, K.,Ogata, M.,Kanemoto, S.,...&Imaizumi, K.(2005).OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.NATURE CELL BIOLOGY,7(2),186-U112. |
MLA | Kondo, S,et al."OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes".NATURE CELL BIOLOGY 7.2(2005):186-U112. |
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