Arid
DOI10.1038/ncb1213
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes
Kondo, S; Murakami, T; Tatsumi, K; Ogata, M; Kanemoto, S; Otori, K; Iseki, K; Wanaka, A; Imaizumi, K
通讯作者Imaizumi, K
来源期刊NATURE CELL BIOLOGY
ISSN1465-7392
EISSN1476-4679
出版年2005
卷号7期号:2页码:186-U112
英文摘要

Endoplasmic reticulum (ER) stress transducers IRE1, PERK and ATF6 are well known to transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. Here, we identified OASIS as a novel ER stress transducer. OASIS is a basic leucine zipper ( bZIP) transcription factor of the CREB/ATF family with a transmembrane domain that allows it to associate with the ER. The molecule is cleaved at the membrane in response to ER stress, and its cleaved amino-terminal cytoplasmic domain, which contains the bZIP domain, translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements. Intriguingly, OASIS was induced at the transcriptional level during ER stress in astrocytes of the central nervous system, but not in other cell types examined. Furthermore, overexpression of OASIS resulted in induction of BiP and suppression of ER-stress-induced cell death, whereas knockdown partially reduced BiP levels and led to ER stress in susceptible astrocytes. Our results reveal pivotal roles for OASIS in modulating the unfolded protein response in astrocytes, and the possibility that cell type-specific UPR signalling also exists in other cells.


类型Article
语种英语
国家Japan
收录类别SCI-E
WOS记录号WOS:000226719500016
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; TRANSCRIPTION FACTOR ; ER STRESS ; MESSENGER-RNA ; GRP78 ; IDENTIFICATION ; EXPRESSION ; APOPTOSIS ; ELEMENT
WOS类目Cell Biology
WOS研究方向Cell Biology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/150015
作者单位(1)Miyazaki Univ, Fac Med, Dept Anat, Miyazaki 8891692, Japan;(2)Nara Inst Sci & Technol NAIST, Div Struct Cellular Biol, Nara 6300101, Japan;(3)Nara Med Univ, Dept Anat, Nara 6348522, Japan;(4)Yamagata Univ, Sch Med, Dept Emergency Med, Yamagata 9909585, Japan
推荐引用方式
GB/T 7714
Kondo, S,Murakami, T,Tatsumi, K,et al. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes[J],2005,7(2):186-U112.
APA Kondo, S.,Murakami, T.,Tatsumi, K.,Ogata, M.,Kanemoto, S.,...&Imaizumi, K.(2005).OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.NATURE CELL BIOLOGY,7(2),186-U112.
MLA Kondo, S,et al."OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes".NATURE CELL BIOLOGY 7.2(2005):186-U112.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Kondo, S]的文章
[Murakami, T]的文章
[Tatsumi, K]的文章
百度学术
百度学术中相似的文章
[Kondo, S]的文章
[Murakami, T]的文章
[Tatsumi, K]的文章
必应学术
必应学术中相似的文章
[Kondo, S]的文章
[Murakami, T]的文章
[Tatsumi, K]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。