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Mineral-nutrient stress is one of the main factors limiting crop production, especially in and lands. The mineral requirement of a crop is difficult to determine, and the interpretation of foliar chemistry composition is not easy. This study was conducted to compute the minimum yield target for fresh fruit of yellow pepper (Capsicum annuum, L.) and the corresponding Compositional Nutrient Diagnosis (CND) as well as to identify significant nutrient interactions of this crop in desert calcareous soils. Preliminary CND norms were developed using a cumulative variance-ratio function and the chi-square distribution function. From a small database, we computed means and standard deviations of row-centered log ratios, V-x, of five nutrients (N, P, K, Ca, and Mg) and a filling value, R, which comprises all nutrients not chemically analyzed and quantified them in 54 foliar samples of the popular yellow pepper cv. ’santa Fe’. This cultivar is widely grown in northwest Mexico under and conditions. These norms are associated to fresh fruit yields higher than 15.04 t ha(-1). Principal-component analyses, performed using estimated CND nutrient indexes, allowed us to identify four interactions: negative P-Ca, P-Mg, and N-K, and positive Ca-Mg. Pepper plants growing on calcareous soils tend to take up more Ca and Mg than considered as optimum in other soil conditions.