Arid
DOI10.1016/S0301-5629(03)00054-1
Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors
Kamotani, Y; Lee, WMF; Arger, PH; Cary, TW; Sehgal, CM
通讯作者Sehgal, CM
来源期刊ULTRASOUND IN MEDICINE AND BIOLOGY
ISSN0301-5629
出版年2003
卷号29期号:7页码:977-984
英文摘要

This study evaluated an image-gating method using contrast-enhanced power Doppler ultrasound (US) to estimate blood perfusion in mice tumors. A mathematical model that compensates for the effect of bubble destruction by US pulses was used to determine contrast flow through an image plane. Multigated power Doppler images were obtained following contrast injection. Contrast flow index (CFI) was determined by measuring the area under the color level vs. time curve for each gating frequency. CFI was compared with true flow. The method was first evaluated using a flow phantom with variable flow rates, and then verified in a mouse model with implanted tumors. Color levels in Doppler images were modulated with gating frequency due to variable destruction of microbubbles by US pulses. CFI measured from the images correlated strongly with true flow in the flow phantom (r(2) = 0.87). The proposed method yielded reproducible CFI for mice tumors, suggesting that multigated contrast-enhanced power Doppler imaging may provide noninvasive measurement of tumor perfusion in mice. (E-mail: sehgal@oasis.rad.upenn.edu) (C) 2003 World Federation for Ultrasound in Medicine Biology.


英文关键词ultrasound contrast agents tumor blood flow tumor perfusion power Doppler imaging microbubbles bubble destruction dilution curves K1735 murine melanoma angiogenesis
类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000184257700009
WOS关键词CONTINUOUS-INFUSION ; ULTRASOUND ; ANGIOGENESIS ; AGENT ; US ; QUANTIFICATION ; MICROBUBBLES ; VASCULARITY ; MODELS
WOS类目Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/145960
作者单位(1)Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA;(2)Univ Penn, Ctr Canc, Philadelphia, PA 19104 USA
推荐引用方式
GB/T 7714
Kamotani, Y,Lee, WMF,Arger, PH,et al. Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors[J],2003,29(7):977-984.
APA Kamotani, Y,Lee, WMF,Arger, PH,Cary, TW,&Sehgal, CM.(2003).Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors.ULTRASOUND IN MEDICINE AND BIOLOGY,29(7),977-984.
MLA Kamotani, Y,et al."Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors".ULTRASOUND IN MEDICINE AND BIOLOGY 29.7(2003):977-984.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Kamotani, Y]的文章
[Lee, WMF]的文章
[Arger, PH]的文章
百度学术
百度学术中相似的文章
[Kamotani, Y]的文章
[Lee, WMF]的文章
[Arger, PH]的文章
必应学术
必应学术中相似的文章
[Kamotani, Y]的文章
[Lee, WMF]的文章
[Arger, PH]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。