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DOI | 10.1016/S0301-5629(03)00054-1 |
Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors | |
Kamotani, Y; Lee, WMF; Arger, PH; Cary, TW; Sehgal, CM | |
通讯作者 | Sehgal, CM |
来源期刊 | ULTRASOUND IN MEDICINE AND BIOLOGY
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ISSN | 0301-5629 |
出版年 | 2003 |
卷号 | 29期号:7页码:977-984 |
英文摘要 | This study evaluated an image-gating method using contrast-enhanced power Doppler ultrasound (US) to estimate blood perfusion in mice tumors. A mathematical model that compensates for the effect of bubble destruction by US pulses was used to determine contrast flow through an image plane. Multigated power Doppler images were obtained following contrast injection. Contrast flow index (CFI) was determined by measuring the area under the color level vs. time curve for each gating frequency. CFI was compared with true flow. The method was first evaluated using a flow phantom with variable flow rates, and then verified in a mouse model with implanted tumors. Color levels in Doppler images were modulated with gating frequency due to variable destruction of microbubbles by US pulses. CFI measured from the images correlated strongly with true flow in the flow phantom (r(2) = 0.87). The proposed method yielded reproducible CFI for mice tumors, suggesting that multigated contrast-enhanced power Doppler imaging may provide noninvasive measurement of tumor perfusion in mice. (E-mail: sehgal@oasis.rad.upenn.edu) (C) 2003 World Federation for Ultrasound in Medicine Biology. |
英文关键词 | ultrasound contrast agents tumor blood flow tumor perfusion power Doppler imaging microbubbles bubble destruction dilution curves K1735 murine melanoma angiogenesis |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000184257700009 |
WOS关键词 | CONTINUOUS-INFUSION ; ULTRASOUND ; ANGIOGENESIS ; AGENT ; US ; QUANTIFICATION ; MICROBUBBLES ; VASCULARITY ; MODELS |
WOS类目 | Acoustics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS研究方向 | Acoustics ; Radiology, Nuclear Medicine & Medical Imaging |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/145960 |
作者单位 | (1)Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA;(2)Univ Penn, Ctr Canc, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Kamotani, Y,Lee, WMF,Arger, PH,et al. Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors[J],2003,29(7):977-984. |
APA | Kamotani, Y,Lee, WMF,Arger, PH,Cary, TW,&Sehgal, CM.(2003).Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors.ULTRASOUND IN MEDICINE AND BIOLOGY,29(7),977-984. |
MLA | Kamotani, Y,et al."Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors".ULTRASOUND IN MEDICINE AND BIOLOGY 29.7(2003):977-984. |
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