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The question whether the mid-Holocene climate (between ca. 9 and 4 cal kyr B.P.) in the Atacama Desert and the Central Andes in general was humid or dry has wide implications with regard to the understanding of long-term climate variability in South America. Paleosols, regional groundwater tables, abiotic proxy data and pollen of aquatic plants in lake sediments.; show a marked and rapid shift from very humid late-glacial/early Holocene climatic conditions (between ca. 14 and 9.5 kyr B.P.) to extremely dry mid-Holocene conditions (more and than today between ca. 9 and 4 kyr B.P.). An exception during this hyperarid period is a century-scale more humid interval around ca. 5.5-6 kyr B.P. that appears systematically in lake sediment archives. In contrast, pollen for most terrestrial plants preserved in lake sediments do not show major changes during the Holocene, whereas more humid mid-Holocene conditions (compared with late Holocene conditions) were inferred from plant macrofossils in rodent middens. Is the reason for.. this disagreement to be attributed to misinterpretation of the paleoenvironments or of the proxy records themselves’, or to incomplete paleoclimatic interpretation of the paleoenvironments? We argue that these different paleoclimate archives record different aspects and facets of ’climate’. While paleosols and groundwater in the Atacama Desert record low-frequency climate variability at century to millennium scales, lake sediments on the Altiplano record decade- to century-scale variability. Terrestrial vegetation responds to shorter high-frequency climate variability at seasonal to, inter-annual scales and preferably to humid years. Vegetation remains in ’hibernation’ or does not germinate during and years. Thus information from these three types of archives is not a priori comparable and requires careful site-specific, archive-specific and time-scale-specific evaluation. What is natural in modem climatology is also true for paleoclimatology: a comprehensive assessment must account for the complex daily and seasonal cycles, for the range of climate variability and trends at different scales in space and time, for impacts of short-term extreme events, and for specific, often non-linear responses of individual bio-geo-physical archives to any of the numerous aspects of ’climate’. (C) 2003 Elsevier Science B.V. All rights reserved.