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Hard red winter wheat (Triticum aestivum L.) is a major crop in the Great Plains region of the U. S. The goal of this assessment effort was to investigate the influence of two contrasting global climate change projections (U. K. Hadley Center for Climate Prediction and Research and Canadian Centre for Climate Modelling and Analysis) on the yield and percent kernel nitrogen content of winter wheat at three locations in Nebraska. These three locations represent sub-humid and semi arid areas and the transition between these areas and are also representative of major portions of the winter wheat growing areas of the central Great Plains. Climate scenarios based on each of the projections for each location were developed using the LARS-WG weather generator along with data from automated weather stations. CERES-Wheat was used to simulate the responses for two contrasting cultivars of wheat using two sowing dates. The first sowing date represented current sowing dates appropriate for each location. The second sowing date was later and represents the approximate date when the mean air temperature from the climate scenarios is the same as the mean air temperature from the actual climate data at the current sowing dates. The yield and percent kernel nitrogen content using the two climate scenarios generally decrease going from the sub-humid eastern to the semi arid western parts of Nebraska. Results from these simulations indicate that yield and percent kernel nitrogen content using the two climate scenarios could not both be maintained at levels currently simulated. Protein content (directly related to kernel nitrogen content) and end-use quality are the primary determinants for the use of hard red winter wheat in baked goods. Nitrogen management and new cultivars, which can enhance the uptake and translocation of nitrogen, will be proactive steps to meet the challenges of global climate change as represented by these climate scenarios.