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The mid-Holocene in China is traditionally thought to be a warm and humid period with a strong summer monsoon, and is often termed the Holocene Climatic Optimum or Megathermal Period. Here we present lake geomorphologic and lithological evidence from the Alashan Plateau, part of the Mongolian Plateau, that indicates strong lake desiccation during the mid-Holocene. High resolution pollen data from Zhuyeze Lake, at the present summer monsoon margin, is also presented. These data show that present lakes and wetlands in the Juyanze Lake basin west of the Badain Jaran desert, in the Zhuyeze Lake basin between the Badain Jaran and Tengger deserts, and in lakes in the eastern Tengger desert, dried or experienced low lake levels in the mid-Holocene around 5000-7000 cal yr BP. Pollen data further indicate that the vegetation cover declined in both the local areas and in the Qilian Mountains, suggesting the climate was drier than that associated with the present Asian summer monsoon. This mid-Holocene drought interval was present throughout a quite large region of the south Inner Mongolian Plateau. The period was also probably colder, at least in the high Asian plateaus and mountains.