干旱区生态环境知识资源中心(Arid): A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1

Arid

DOI	10.1046/j.1365-2133.2003.05178.x
	A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1
	Endo, H; Utani, A; Matsumoto, F; Kuroki, T; Yoshimoto, S; Ichinose, M; Shinkai, H
通讯作者	Endo, H
来源期刊	BRITISH JOURNAL OF DERMATOLOGY
ISSN	0007-0963
出版年	2003
卷号	148 期号:2 页码:337-341
英文摘要	Background Hedgehogs (Hhs) and their receptors are involved in organ development as well as in tumorigenesis observed in basal cell carcinoma. Among Hhs, Desert hedgehog secreted from Schwann cells mediates the formation of peripheral nerve sheaths. However, there has been no study on the role of Hhs and their receptors in tumorigenesis of neurofibromas in neurofibromatosis type 1 (NF1). Objectives To clarify the expression and localization of Hhs and their receptors in neurofibromas of NF1 patients. Methods Expression of Hhs and their receptors was studied by immunohistochemistry using neurofibromas from NF1 patients and control normal skin samples. Results In neurofibromas, CD57-positive tumour cells with delicate elongated processes were positive for the receptor PTCH2. Perineurial cells of involved nerves within neurofibromas as well as those of normal cutaneous nerves expressed Indian hedgehog and Sonic hedgehog. Schwann cells of normal cutaneous nerves were positive for PTCH2. Conclusions Our study suggests that a paracrine Hh signalling pathway may be involved in tumorigenesis of neurofibromas in NF1.
英文关键词	Indian hedgehog neurofibroma neurofibromatosis type 1 Patched2 Schwann cell Sonic hedgehog
类型	Article
语种	英语
国家	Japan
收录类别	SCI-E
WOS记录号	WOS:000181051400023
WOS关键词	BASAL-CELL CARCINOMA ; SONIC HEDGEHOG ; SCHWANN-CELLS ; SIGNALING PATHWAY ; PROTEIN ; PRODUCT ; TUMORS ; NERVE ; SKIN ; EXPRESSION
WOS类目	Dermatology
WOS研究方向	Dermatology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/144260
作者单位	(1)Chiba Univ, Grad Sch Med, Dept Clin Biol Extracellular Matrix, Chuo Ku, Chiba 2608670, Japan;(2)Chiba Univ, Grad Sch Med, Dept Plast Surg, Chuo Ku, Chiba 2608670, Japan
推荐引用方式 GB/T 7714	Endo, H,Utani, A,Matsumoto, F,et al. A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1[J],2003,148(2):337-341.
APA	Endo, H.,Utani, A.,Matsumoto, F.,Kuroki, T.,Yoshimoto, S.,...&Shinkai, H.(2003).A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1.BRITISH JOURNAL OF DERMATOLOGY,148(2),337-341.
MLA	Endo, H,et al."A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1".BRITISH JOURNAL OF DERMATOLOGY 148.2(2003):337-341.