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DOI | 10.1007/s00429-003-0311-z |
Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development | |
Hikake, T; Mori, T; Iseki, K; Hagino, S; Zhang, Y; Takagi, H; Yokoya, S; Wanaka, A | |
通讯作者 | Wanaka, A |
来源期刊 | ANATOMY AND EMBRYOLOGY
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ISSN | 0340-2061 |
出版年 | 2003 |
卷号 | 206期号:5页码:373-380 |
英文摘要 | The transcription factor OASIS gene, which encodes for a CREB/ATF family member, is specifically expressed in the salivary gland, the cartilage and the tooth germs of the mouse embryo. In the present study, the expression patterns were compared between OASIS mRNA and major vertebrate proteoglycans, which might be the downstream genes of OASIS in the tooth germs of mouse first mandibular molars, through in situ hybridization histochemistry. OASIS mRNA expression was observed in the inner enamel epithelium during the cap and bell stages (E14.5-E18.5) in the preodontoblasts during differentiation stage (E18.5-P0) and in the differentiating odontoblasts during the early secretory stage (P2.5-P4.5). Proteoglycans (versican, decorin, biglycan, glypican, syndecan-1, and syndecan-3) were expressed in the tooth germs in various patterns. Decorin, biglycan, syndecan-1 and syndecan-3 showed gene expressions overlapping with OASIS. Especially the expression pattern of decorin and syndecan-3 coincided temporally and spatially exactly with that of OASIS. These results suggest that the OASIS gene might be related to proteoglycan expression and may play an important role in the differentiation of the odontoblast and cells in inner enamel epithelium. |
英文关键词 | CREB/ATF family OASIS proteoglycan tooth development |
类型 | Article |
语种 | 英语 |
国家 | Japan |
收录类别 | SCI-E |
WOS记录号 | WOS:000183083100004 |
WOS关键词 | EPITHELIAL MESENCHYMAL INTERACTIONS ; FIBROBLAST GROWTH-FACTORS ; ODONTOBLAST DIFFERENTIATION ; CELL-PROLIFERATION ; FACTOR-BETA ; IN-VITRO ; IGF-I ; MORPHOGENESIS ; SYNDECAN ; TISSUES |
WOS类目 | Anatomy & Morphology ; Developmental Biology |
WOS研究方向 | Anatomy & Morphology ; Developmental Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/144069 |
作者单位 | (1)Nara Med Univ, Dept Anat, Nara 6348521, Japan;(2)Fukushima Med Univ, Sch Med, Inst Biomed Sci, Dept Cell Sci, Fukushima 9601295, Japan |
推荐引用方式 GB/T 7714 | Hikake, T,Mori, T,Iseki, K,et al. Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development[J],2003,206(5):373-380. |
APA | Hikake, T.,Mori, T.,Iseki, K.,Hagino, S.,Zhang, Y.,...&Wanaka, A.(2003).Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.ANATOMY AND EMBRYOLOGY,206(5),373-380. |
MLA | Hikake, T,et al."Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development".ANATOMY AND EMBRYOLOGY 206.5(2003):373-380. |
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