Arid
DOI10.1007/s00429-003-0311-z
Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development
Hikake, T; Mori, T; Iseki, K; Hagino, S; Zhang, Y; Takagi, H; Yokoya, S; Wanaka, A
通讯作者Wanaka, A
来源期刊ANATOMY AND EMBRYOLOGY
ISSN0340-2061
出版年2003
卷号206期号:5页码:373-380
英文摘要

The transcription factor OASIS gene, which encodes for a CREB/ATF family member, is specifically expressed in the salivary gland, the cartilage and the tooth germs of the mouse embryo. In the present study, the expression patterns were compared between OASIS mRNA and major vertebrate proteoglycans, which might be the downstream genes of OASIS in the tooth germs of mouse first mandibular molars, through in situ hybridization histochemistry. OASIS mRNA expression was observed in the inner enamel epithelium during the cap and bell stages (E14.5-E18.5) in the preodontoblasts during differentiation stage (E18.5-P0) and in the differentiating odontoblasts during the early secretory stage (P2.5-P4.5). Proteoglycans (versican, decorin, biglycan, glypican, syndecan-1, and syndecan-3) were expressed in the tooth germs in various patterns. Decorin, biglycan, syndecan-1 and syndecan-3 showed gene expressions overlapping with OASIS. Especially the expression pattern of decorin and syndecan-3 coincided temporally and spatially exactly with that of OASIS. These results suggest that the OASIS gene might be related to proteoglycan expression and may play an important role in the differentiation of the odontoblast and cells in inner enamel epithelium.


英文关键词CREB/ATF family OASIS proteoglycan tooth development
类型Article
语种英语
国家Japan
收录类别SCI-E
WOS记录号WOS:000183083100004
WOS关键词EPITHELIAL MESENCHYMAL INTERACTIONS ; FIBROBLAST GROWTH-FACTORS ; ODONTOBLAST DIFFERENTIATION ; CELL-PROLIFERATION ; FACTOR-BETA ; IN-VITRO ; IGF-I ; MORPHOGENESIS ; SYNDECAN ; TISSUES
WOS类目Anatomy & Morphology ; Developmental Biology
WOS研究方向Anatomy & Morphology ; Developmental Biology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/144069
作者单位(1)Nara Med Univ, Dept Anat, Nara 6348521, Japan;(2)Fukushima Med Univ, Sch Med, Inst Biomed Sci, Dept Cell Sci, Fukushima 9601295, Japan
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Hikake, T,Mori, T,Iseki, K,et al. Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development[J],2003,206(5):373-380.
APA Hikake, T.,Mori, T.,Iseki, K.,Hagino, S.,Zhang, Y.,...&Wanaka, A.(2003).Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.ANATOMY AND EMBRYOLOGY,206(5),373-380.
MLA Hikake, T,et al."Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development".ANATOMY AND EMBRYOLOGY 206.5(2003):373-380.
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