Arid
DOI10.2174/1381612023395718
Trypsin and chymotrypsin inhibitors in insects and gut leeches
Schoofs, L; Clynen, E; Salzet, M
通讯作者Schoofs, L
来源期刊CURRENT PHARMACEUTICAL DESIGN
ISSN1381-6128
EISSN1873-4286
出版年2002
卷号8期号:7页码:483-491
英文摘要

The constant increase of life expectancy is associated with major ageing of developed populations. This indicates that the new century will have one of most epidemic progressions of cardiovascular, cancer and inflammatory diseases. The high challenge for medical research is to compress such morbidity. In these conditions, invertebrates have demonstrated to be truly useful models in drug discovery for such ageing diseases. The last decade, drug discovery in leeches has opened the gate of new molecules to treat emphysema, coagulation, inflammation, dermitis and cancer. Also other invertebrates such as insects, which evolved from the annelids, harvest potential interesting molecules, such as serine protease inhibitors that can be exploited by the medical industry.


类型Review
语种英语
国家Belgium ; France
收录类别SCI-E
WOS记录号WOS:000174767700002
WOS关键词AMINO-ACID-SEQUENCE ; SERINE-PROTEASE INHIBITORS ; PROTEINASE-INHIBITORS ; THEROMYZON TESSULATUM ; LOCUSTA-MIGRATORIA ; SCHISTOCERCA-GREGARIA ; DESERT LOCUST ; BIOCHEMICAL-CHARACTERIZATION ; RHYNCHOBDELLID LEECH ; BIOLOGICAL-ACTIVITY
WOS类目Pharmacology & Pharmacy
WOS研究方向Pharmacology & Pharmacy
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/142394
作者单位(1)Katholieke Univ Leuven, Lab Dev Physiol & Mol Biol, B-3000 Louvain, Belgium;(2)Univ Sci & Technol, Lab Neuroimmunol Annelides, CNRS, INSERM,ESA 8017,SN3,IFR17, F-59655 Villeneuve Dascq, France
推荐引用方式
GB/T 7714
Schoofs, L,Clynen, E,Salzet, M. Trypsin and chymotrypsin inhibitors in insects and gut leeches[J],2002,8(7):483-491.
APA Schoofs, L,Clynen, E,&Salzet, M.(2002).Trypsin and chymotrypsin inhibitors in insects and gut leeches.CURRENT PHARMACEUTICAL DESIGN,8(7),483-491.
MLA Schoofs, L,et al."Trypsin and chymotrypsin inhibitors in insects and gut leeches".CURRENT PHARMACEUTICAL DESIGN 8.7(2002):483-491.
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