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Study on two loess sections, one located at Wuwei near the Tengger Desert in northwestern China, another located near Ganzi at the southeast margin of the Tibetan Plateau in southwest China, reveals a coeval drying step occurred at similar to250 kaBP. It is expressed by the increase in eolian grain-size at Wuwei, and by a drastic extension of C4 plants and a decrease of loess chemical weathering intensity at Ganzi. Examination of the available eolian data indicates that the event has also been clearly documented in the loess sections near the deserts in northern China, and in the eolian records from the North Pacific. On the contrary, the signal is rather weak for the central and southern Loess Plateau regions as well as for Central Asia, where the climates are influenced by the southeast Asian monsoon and the westerlies, respectively. Since the climate at Ganzi is under strong control of the southwest Asian monsoon, we interpret this drying step as a result of decreased influence of the southwest summer monsoon. This decrease in monsoon moisture is attributable to the uplift of the Hengduan Mountains, the southeast margin of the Tibetan Plateau at similar to250 ka ago.