Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1046/j.1365-3156.2001.00802.x |
Population structure of Plasmodium falciparum isolates during an epidemic in southern Mauritania | |
Jordan, S; Jelinek, T; Aida, AO; Peyerl-Hoffmann, G; Heuschkel, C; el Valy, AO; Christophel, EM | |
通讯作者 | Jelinek, T |
来源期刊 | TROPICAL MEDICINE & INTERNATIONAL HEALTH
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ISSN | 1360-2276 |
出版年 | 2001 |
卷号 | 6期号:10页码:761-766 |
英文摘要 | While the population structure of Plasmodium falciparum is well analysed in selected areas with high malaria endemicity in East and West Africa, only limited data are available for low endemicity regions bordering the Saharan desert. This is one of the first studies for the Sahel, where atypically strong rainfalls in 1998 and 1999 led to a severe outbreak of falciparum malaria in south-east Mauritania. During a study on in vivo-drug resistance against chloroquine we collected blood samples of patients with fever in two medical centres located in non-endemic and hypoendemic areas. We analysed 386 samples by polymerase chain reaction for infection with P. falciparum, and 173 (45%) tested positive. The isolates were genotyped for three polymorphic genetic markers: merozoite surface protein I (MSPI), MSP2 and glutamate-rich protein (GLURP). Differences between the two regions could be shown in either number of clones per infection or in their distribution on the different allelic groups. While the mean minimal number of clones in the non-endemic region around Aioun was 1.57, blood samples collected in the hypoendemic region around Kobeni showed multiple infections with an average of 2.34 clones (P < 0.001). In addition, clear differences between endemic regions were apparent in three of the investigated allelic groups: RO33 of the MSPI gene and FC and Indochina of the MSP2 gene. |
英文关键词 | malaria Plasmodium falciparum genotyping |
类型 | Article |
语种 | 英语 |
国家 | Germany ; Mauritania |
收录类别 | SCI-E |
WOS记录号 | WOS:000171475600004 |
WOS关键词 | POLYMERASE-CHAIN-REACTION ; GENETIC DIVERSITY ; MALARIA PARASITES ; SENSITIVITY |
WOS类目 | Public, Environmental & Occupational Health ; Tropical Medicine |
WOS研究方向 | Public, Environmental & Occupational Health ; Tropical Medicine |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/141856 |
作者单位 | (1)Univ Munich, Dept Trop Med & Infect Dis, D-80802 Munich, Germany;(2)Direct Reg Act Sociale & Sante, Hodh El Gharbi, Mauritania;(3)Projet Lutte Contre Paludisme Integre Dans Soins, Nonakchott, Mauritania;(4)GTZ, Projet Sante Base Hodh El Gharbi, Hodh El Gharbi, Mauritania |
推荐引用方式 GB/T 7714 | Jordan, S,Jelinek, T,Aida, AO,et al. Population structure of Plasmodium falciparum isolates during an epidemic in southern Mauritania[J],2001,6(10):761-766. |
APA | Jordan, S.,Jelinek, T.,Aida, AO.,Peyerl-Hoffmann, G.,Heuschkel, C.,...&Christophel, EM.(2001).Population structure of Plasmodium falciparum isolates during an epidemic in southern Mauritania.TROPICAL MEDICINE & INTERNATIONAL HEALTH,6(10),761-766. |
MLA | Jordan, S,et al."Population structure of Plasmodium falciparum isolates during an epidemic in southern Mauritania".TROPICAL MEDICINE & INTERNATIONAL HEALTH 6.10(2001):761-766. |
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