干旱区生态环境知识资源中心

Neuroparsins were originally identified in locust corpus cardiacum extracts as folliculostatic or ’antigonadotropic’ neuropeptides. This paper presents the cloning of two different neuroparsin precursor cDNAs from the brain of the desert locust, Schistocera gregaria, The first transcript encodes the precursor (Scg-NPP1) of S, gregeria neuroparsin A and B, whereas the second codes for a novel neuroparsin-related peptide precursor (Scg-NPP2), Both precursors display significant sequence similarities with each other and with the Locusts migratoria neuroparsin (Lom-NPP) and Aedes aegypti ovary ecdysteroidogenic hormone (Aea-OEH1) precursors. Northern blot analysis revealed that these neuroparsin transcripts are present in larval and adult locust brains. Interestingly, the Scg-NPP2 mRNA content proved to be strongly regulated during the reproductive cycle in bath adult males and females.