Arid
DOI10.1081/AL-100107525
Sensitive analysis of tetrodotoxin in human plasma by solid-phase extractions and gas chromatography/mass spectrometry
Kurono, S; Hattori, H; Suzuki, O; Yamada, T; Seno, H
通讯作者Seno, H
来源期刊ANALYTICAL LETTERS
ISSN0003-2719
出版年2001
卷号34期号:14页码:2439-2446
英文摘要

A method to determine tetrodotoxin (TTX) in human plasma by solid-phase extractions and gas chromatography/mass spectrometry (GC/MS) is described. TTX in plasma samples was passed through Sep-Pak PS-2 extraction cartridges, Then the compound was converted to 2-amino-6-hydroxymethyl-8-hydroxyquinazoline (C9-base) under alkaline conditions and extracted with use of an OASIS HLB extraction cartridge. The C9-base was analyzed after trimethylsilyl derivatization by GC/MS-selected ion monitoring. Recovery rates were 35.3-50.8% and their coefficients of variation were not greater than 16.6%. The calibration curve was linear in the range of 0.5-10.0 ng ml(-1) and the detection limit was 0.1 ng ml(-1). The coefficients of within-day and day-to-day variations were not greater than 11.8%. Actual determination of TTX in rat plasma after intraperitoneal administration was also presented.


英文关键词tetrodotoxin C9-base human plasma solid-phase extraction Sep-Pak PS2 OASIS HLB gas chromatography/mass spectrometry
类型Article
语种英语
国家Japan
收录类别SCI-E
WOS记录号WOS:000172315500003
WOS类目Chemistry, Analytical
WOS研究方向Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/140229
作者单位(1)Aichi Med Univ, Sch Med, Dept Legal Med, Nagakute, Aichi 4801195, Japan;(2)Hamamatsu Univ Sch Med, Dept Legal Med, Hamamatsu, Shizuoka 4313192, Japan
推荐引用方式
GB/T 7714
Kurono, S,Hattori, H,Suzuki, O,et al. Sensitive analysis of tetrodotoxin in human plasma by solid-phase extractions and gas chromatography/mass spectrometry[J],2001,34(14):2439-2446.
APA Kurono, S,Hattori, H,Suzuki, O,Yamada, T,&Seno, H.(2001).Sensitive analysis of tetrodotoxin in human plasma by solid-phase extractions and gas chromatography/mass spectrometry.ANALYTICAL LETTERS,34(14),2439-2446.
MLA Kurono, S,et al."Sensitive analysis of tetrodotoxin in human plasma by solid-phase extractions and gas chromatography/mass spectrometry".ANALYTICAL LETTERS 34.14(2001):2439-2446.
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