Arid
DOI10.1016/S0035-9203(99)90027-5
Dengue haemorrhagic fever in children in the 1996 Delhi epidemic
Kabra, SK; Jain, Y; Pandey, RM; Madhulika; Singhal, T; Tripathi, P; Broor, S; Seth, P; Seth, V
通讯作者Kabra, SK
来源期刊TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
ISSN0035-9203
出版年1999
卷号93期号:3页码:294-298
英文摘要

An epidemic of dengue haemorrhagic fever (DHF) occurred in Delhi in 1996. A total of 240 children between the age of 4 months to 13 years of either sex, admitted in one hospital, were evaluated. Two hundred arid sixteen (90%) children were from Delhi. A clinical diagnosis of dengue fever (DF) was made in 25 (10%), dengue fever with unusual bleeding (DFB) in 22 (9%), DHF in 80 (33%) and dengue shock syndrome (DSS) in 113 (47%) of the children strictly according to the WHO classification. The age peaked at 8 years. There was no association between various grades of severity of illness and age-groups though girls suffered from more severe illness. No association between severity of malnutrition and severity of illness was observed. Tourniquet test was positive in 40% with DF, 18% with DFB, 62% with DHF and 64% with DSS. In DSS haematemesis was present in 55 (49%), epistaxis in 39 (35%), melaena in. 27 (24%) and ecchymosis in 34 (30%) patients. Children diagnosed as DFB had haematemesis and epistaxis in 12 (55%) and 10 (45%) respectively. Intravenous fluid requirement was clearly less in DFB patients than in DHF/DSS patients. Unusual clinical features in the form of jaundice were present in 7 (6%), hepatic encephalopathy in 6 (5%) and dengue encephalopathy in 6 (5%) patients. Dengue 2 virus was isolated from 10 of the 50 patients for whom viral culture was done on C6/36 clone of Aedes albopictus cell line. Eighteen patients suffering from DSS died giving an overall case fatality of 7.5%. The mortality rate in DHF/DSS was 9.3%. It is further suggested that DFB is a distinct entity. Most patients could be classified by the WHO classification if a retrospective packed cell volume was used to assess haemoconcentration. We suggest that development of area-specific criteria for diagnosis and management is desirable.


英文关键词dengue haemorrhagic fever children clinical aspects dengue 2 virus India
类型Article
语种英语
国家India
收录类别SCI-E
WOS记录号WOS:000081460500019
WOS关键词HEMORRHAGIC-FEVER ; SHOCK SYNDROME ; ENCEPHALITIS
WOS类目Public, Environmental & Occupational Health ; Tropical Medicine
WOS研究方向Public, Environmental & Occupational Health ; Tropical Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/138281
作者单位(1)All India Inst Med Sci, Dept Pediat, New Delhi 110029, India;(2)All India Inst Med Sci, Dept Microbiol, New Delhi 110029, India;(3)All India Inst Med Sci, Dept Biostat, New Delhi 110029, India
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GB/T 7714
Kabra, SK,Jain, Y,Pandey, RM,et al. Dengue haemorrhagic fever in children in the 1996 Delhi epidemic[J],1999,93(3):294-298.
APA Kabra, SK.,Jain, Y.,Pandey, RM.,Madhulika.,Singhal, T.,...&Seth, V.(1999).Dengue haemorrhagic fever in children in the 1996 Delhi epidemic.TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE,93(3),294-298.
MLA Kabra, SK,et al."Dengue haemorrhagic fever in children in the 1996 Delhi epidemic".TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 93.3(1999):294-298.
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