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In planta gene targeting can be enhanced by the use of CRISPR/Cas12a 期刊论文
发表期刊: PLANT JOURNAL. 出版年: 2019, 卷号: 100, 期号: 5, 页码: 1083-1094
作者:  Wolter, Felix;  Puchta, Holger
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/29
CRISPR  Cas  genome editing  genome instability  double-strand break repair  homologous recombination  RTEL-1  Fanconi anaemia  blooms syndrome  Arabidopsis thaliana  technical advance  
Project 1 - Disruption of CpG island-mediated gene regulation and chromatin architecture in progeria and aging 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2019-
负责人:  BECK, SAMUEL
收藏  |  浏览/下载:25/0  |  提交时间:2021/08/12
Address  Age of Onset  age related  Aging  Architecture  Atherosclerosis  Biological  Biology of Aging  Biomedical Research  Blindness  Cardiac Myocytes  Cell Differentiation process  Cells  Chromatin  Chromosome Mapping  Comparative Biology  CpG Islands  CRISPR/Cas technology  Cytosine  Data Set  de novo mutation  Defect  Degenerative Disorder  Dinucleoside Phosphates  Disease  DNA  DNA Damage  DNA Repair  Economics  Elements  epigenetic regulation  Euchromatin  Fatty Liver  Fluorescent in Situ Hybridization  Frequencies  Gene Expression  Gene Expression Regulation  Genes  Genetic  Genetic Transcription  genome editing  genome-wide  Genomic Instability  Goals  Guanine  Hair  Hepatocyte  Heterochromatin  Impairment  induced pluripotent stem cell  innovation  inorganic phosphate  insight  Lamin Type A  Lamins  Life  Life Expectancy  Link  Mediating  Meta-Analysis  Modeling  Molecular  Morphology  mRNA sequencing  Musculoskeletal  Mutation  Natural regeneration  Nuclear  Nuclear Lamin  Nuclear Lamina  Pathology  Patients  Peripheral  Physiological  Predisposition  prevent  Process  Progeria  promoter  Property  Proteins  Psyche structure  Public Health  Regulation  Resources  response  restoration  Skin  Structural Protein  Symptoms  Testing  therapy development  tissue repair  Tissues  Undifferentiated  
Genetic variations in colorectal cancer risk and clinical outcome 期刊论文
发表期刊: WORLD JOURNAL OF GASTROENTEROLOGY. 出版年: 2014, 卷号: 20, 期号: 15, 页码: 4167-4177
作者:  Zhang, Kejin;  Civan, Jesse;  Mukherjee, Sushmita;  Patel, Fenil;  Yang, Hushan
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/29
Colorectal cancer  Genome-wide association study  Single nucleotide polymorphism  Signal transduction pathways  Cell cycle control  Gene desert  Genome instability