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Validation and application of a method for the determination of nicotine and five major metabolites in smokers’ urine by solid-phase extraction and liquid chromatography tandem mass spectrometry 期刊论文
发表期刊: BIOMEDICAL CHROMATOGRAPHY. 出版年: 2005, 卷号: 19, 期号: 4, 页码: 312-328
作者:  Heavner, DL;  Richardson, JD;  Morgan, WT;  Ogden, MW
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cotinine  trans-3 ’-hydroxycotinine  nicotine-N-glucuronide  cotinine-N-glucuronide  trans-3 ’-hydroxycotinine-O-glucuronide  nicotine equivalents  creatinine  beta-lucuronidase  LC-MS/MS  method validation  diurnal variation  elimination half-life  metabolite distribution  conjugation profile