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| Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis 项目
项目编号: 1R21AI149015-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2021
负责人: HUNG, CHIUNG YU
  收藏 | 浏览/下载：6/0 | 提交时间：2021/08/12
acute infection Adverse effects Affect Americas Amphotericin B Animals Antifungal Agents Antimicrobial Resistance Area base Biological Assay Caliber Caspofungin Cell Membrane Permeability Cell Wall Cells chemotherapy Clinical Coccidioides Coccidioides immitis Coccidioides posadasii Coccidioidomycosis Communities Containment Contracts cost Cryptococcus Cryptococcus neoformans Cytochrome P450 Cytology cytotoxicity Data Databases desert fever Development Diagnosis Disease Dose drug development Drug usage drug use screening Flow Cytometry Fluconazole follow-up fungus Goals Government Growth Hand Human Hyphae Image In Vitro in vivo Incubated indexing Infection Inhalation insight Lead Legal patent Libraries Life Cycle Stages Lower respiratory tract structure Lung Lung diseases Medical Medical Research Meningitis Methods Mexico Microscope Morphology Motivation Mycoses Neuraxis novel novel strategies novel therapeutics off-patent pathogen pathogenic fungus Patients Pharmaceutical Preparations Pharmacology Phase IV Clinical Trials Phenotype Pneumonia preclinical development prevent Process Property Reporting Reproduction spores Research Personnel resistant strain Resolution screening small molecule libraries Soil South America Southwestern United States Speed success Symptoms synergism Techniques Testing The science of Mycology Time Toxic effect United States United States National Institutes of Health Vaccines |
| Regulatory T cell function in predicting Valley fever outcomes 项目
项目编号: 1R21AI142261-01A1. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: HOYER, KATRINA K.
收藏 | 浏览/下载：16/0 | 提交时间：2021/08/12
Activities of Daily Living Acute acute infection adaptive immune response Adult Aftercare Age Algorithms Antibiotic Therapy Antifungal Agents Area Arizona Bacterial Infections base Biological Factors Biological Markers Blood California Case Study Cell physiology Cells Cessation of life Child Childhood Chronic Chronic Disease chronic infection Clinic Clinical Coccidioides Coccidioides immitis Coccidioides posadasii Coccidioidomycosis Contracts Data Data Set desert fever Detection Diagnosis Diagnostic Disease Disease Outcome Dust eosinophil Evaluation experience flu Frequencies fungus Health Immune Immune response Immunity Immunologic Factors Immunologic Markers Impaired health improved Incidence Infection Inhalation Knowledge Lung nodule Measurement Methods Mexico Modeling Monitor Mus neutrophil novel older patient Outcome pathogenic fungus Patient Care Patients pediatric patients peripheral blood Pharmaceutical Preparations Phenotype Population prediction algorithm Predictive Factor predictive modeling predictive test prevent Recurrent disease Regulatory T-Lymphocyte Relapse research study Resolution response Severities Severity of illness side effect Soil South America Southwestern United States Symptoms Testing Time tool Translational Research transmission process Travel Vaccines Washington Weather |
| Splice modulatory therapy for valley fever 项目
项目编号: 1R21AI154106-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: BURKART, MICHAEL D.
收藏 | 浏览/下载：6/0 | 提交时间：2021/08/12
Acute Myelocytic Leukemia Amphotericin B analog anti-cancer Antifungal Agents Arizona Azoles base Biological Biological Markers Biology California cancer cell Cells Chemicals Clinical Coccidioides immitis Coccidioides posadasii Coccidioidomycosis combat Communities desert fever design Development Diagnosis Disease Drug Interactions Dust Evaluation Event Family flu Fluconazole Funding fungus Future Genes Goals high reward high risk Human Incidence Individual Infection Investigation Laboratories Lead Left Life Messenger RNA Modernization Natural Products new therapeutic target next generation novel Oncogenic Outcome outcome forecast Pathway interactions Patients Pattern Pharmaceutical Chemistry Pharmaceutical Preparations Play Pneumonia Positioning Attribute Precipitation preclinical study Preparation programs Reporting RNA Splicing scaffold Seasons Series Side side effect small molecule Spliceosomes Structure System Systems Biology Techniques Testing Therapeutic therapeutic target tool transcriptome transcriptomics Translating Translations United States Work |
| Project 1 - Environmental Project 1 - EP1 - Immobilization of U, As, and Co-occurring Metals in Mine Wastes 项目
项目编号: 5P42ES025589-04. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: CERRATO, JOSE MANUEL
收藏 | 浏览/下载：4/0 | 提交时间：2021/08/12
Address Adsorption Aerobic Affect Amendment aqueous Basic Science bioaccumulation Biological Carbonates Characteristics Chemicals Chemistry Climate Climate Controls Collaborations Communities Complement contaminated drinking water cultural values Custom Decision Making Desert Climate Development Ecology Engineering Environment Environmental Engineering technology Environmental Microbiology experience experimental study Exposure to Exudate Geographic Factor Goals Hazardous Substances Hazardous Waste Sites Health Home environment Human IGFBP2 gene Immobilization In Vitro Individual Ingestion innovation inorganic phosphate interfacial Intervention iron oxide Knowledge Laboratories Ligands mathematical model Measures member metagenome Metal exposure metal poisoning Metals Methods microbiome microbiome alteration microorganism Microscopy migration Minerals Mining Modeling Molecular Native Americans Navajo New Mexico next generation sequencing Outcomes Research Oxides Pattern Phase Pilot Projects Plant Roots Plants Play Population Precipitation prevent Process programs Pueblo Race Rain Reaction remediation Research Resources Risk Risk Reduction Role Sampling Science Scientist Seasons Site Soil Source Spectrum Analysis Superfund Surface System Techniques Testing tool Toxic effect toxic metal tribal community tribal lands Tribes Underserved Population Universities uptake Uranium wasting Water water flow |
| Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人: KHANNA, RAJESH
收藏 | 浏览/下载：14/0 | 提交时间：2021/08/12
Absence of pain sensation addiction Affect Afferent Neurons American Amitriptyline Analgesics analog Antidepressive Agents Arizona Axon Baclofen base Betulinic Acid Biological Assay biophysical properties Calcium Calcium Channel Blockers Calcium Channel Inhibition cancer pain Cancer Patient cancer survival cancer therapy Cell-Mediated Cytolysis Cells central sensitization chemotherapeutic agent chemotherapy Chemotherapy-induced peripheral neuropathy Chemotherapy-Oncologic Procedure Chronic chronic pain chronic pain relief chronic painful condition Clinical Clinical Trials Complex compliance behavior Complication counterscreen Coupled design dorsal horn Dose-Limiting drug discovery Drug Kinetics Drug Targeting duloxetine Dysesthesias effective therapy Effectiveness Esthesia Feeling Fiber G-Protein-Coupled Receptors Human improved In Vitro in vivo Indigenous inhibitor/antagonist Ion Channel Laboratories Lavandula Lead Malignant Neoplasms Mediating Mediator of activation protein Medical Medicinal Plants meetings Modeling Muscle relaxants Natural Products Neuraxis neuronal excitability Neurons Neuropathy neurotoxic neurotoxicity neurotransmission non-opioid analgesic Norepinephrine novel novel therapeutics Numbness Opiate Addiction Opioid opioid misuse Opioid Receptor opioid sparing opioid use Oral Paclitaxel Pain Pain management pain model pain relief pain signal painful neuropathy Paresthesia Pathogenesis Pathway interactions Peripheral Peripheral Nerves Peripheral Nervous System Peripheral Nervous System Diseases Pharmaceutical Preparations Pharmacology Pharmacotherapy Phase Plants Platinum Compounds preclinical study Prevalence Property Protein Isoforms Proteins Quality of life Rattus Regimen Regulation reuptake Role Safety screening Sensory sensory stimulus Serotonin Shock side effect Site small molecule somatosensory Southwestern United States Specificity Spinal Spinal Cord Spinal Ganglia Structure success Survival Rate synaptic function T-Type Calcium Channels taxane Testing Tissues Translating Treatment Protocols Universities venlafaxine Vinca Alkaloids voltage Work |
| Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis 项目
项目编号: 5R21CA205932-02. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-2020
负责人: BAKER, BILL J; CHAIN, PATRICK S. G.; MURRAY, ALISON ELIZABETH (contact)
收藏 | 浏览/下载：3/0 | 提交时间：2021/08/12
3-hydroxy-3-methylglutaryl-coenzyme A Anabolism Antarctic Architecture ascidian Atmosphere Bacteria Bacterial Genome base Base Sequence Bioinformatics cancer therapy candidate validation cell growth Cell Line cell type Cells chemotherapeutic agent chemotherapy Clinical Code contig Cytostatics cytotoxicity Data Development Diagnosis Disease drug development Drug Targeting fighting Gene Cluster Genes genetic manipulation Genome Genome Mappings genome sequencing Genomics Goals Harvest High-Risk Cancer Human Cell Line Hybrids Immunotherapy In Vitro indexing insight interest Ligase Macrolides Marines markov model Melanins melanocyte melanoma Melanoma Cell metagenome metagenomic sequencing Metastatic Melanoma microbial microbiome microorganism Mining Modeling Molecular Mutagenesis Natural Products New Agents next generation novel Organism Outcomes Research Pathway interactions peptide synthase Pharmaceutical Preparations Pharmacology polyketide synthase Preparation Procedures Production Proton Pump reference genome Research research and development Resistance Resistance development Ribosomal RNA Risk scale up screening Signal Transduction Pathway Skin Skin Cancer Source Specificity Specimen stratospheric ozone Structure Survival Rate symbiont System targeted agent Therapeutic tool Toxic effect Treatment Efficacy tumor Ultraviolet Rays United States vacuolar H+-ATPase whole genome |
| Project 1 - Environmental Project 1 - EP1 - Immobilization of U, As, and Co-occurring Metals in Mine Wastes 项目
项目编号: 5P42ES025589-02. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-
负责人: CERRATO, JOSE MANUEL
收藏 | 浏览/下载：3/0 | 提交时间：2021/08/12
Address Adsorption Aerobic Affect Amendment aqueous Basic Science bioaccumulation Biological Carbonates Characteristics Chemicals Chemistry Climate Climate Controls Collaborations Communities Complement contaminated drinking water cultural values Custom Decision Making Desert Climate Development Ecology Engineering Environment Environmental Engineering technology Environmental Microbiology experience experimental study Exposure to Exudate Geographic Factor Goals Hazardous Substances Hazardous Waste Sites Health Home environment Human IGFBP2 gene Immobilization In Vitro Individual Ingestion innovation inorganic phosphate interfacial Intervention Knowledge Laboratories Ligands mathematical model Measures member metagenome Metal exposure metal poisoning Metals Methods microbiome microbiome alteration microorganism Microscopy migration Minerals Mining Modeling Molecular Native Americans Navajo New Mexico next generation sequencing Outcomes Research Oxides Pattern Phase Pilot Projects Plant Roots Plants Play Population Precipitation prevent Process programs Pueblo Race Rain Reaction remediation Research Resources Risk Risk Reduction Role Sampling Science Scientist Seasons Site Soil Source Spectrum Analysis Superfund Surface System Techniques Testing tool Toxic effect toxic metal tribal community tribal lands Tribes Underserved Population Universities uptake Uranium wasting Water water flow |
| Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust 项目
项目编号: 5P42ES004940-29. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-
负责人: ZHANG, DONNA D
收藏 | 浏览/下载：5/0 | 提交时间：2021/08/12
Adverse effects Affect airway epithelium Alveolar Arsenic Autophagocytosis base Binding Biological Assay Biological Markers Bronchiectasis Butter Carcinogens Cells Chemopreventive Agent Chronic Chronic Bronchitis Chronic Obstructive Airway Disease CRISPR/Cas technology Cytosol Data defense response Degradation Pathway Desert Climate Development Diet Dietary Supplementation Disease disease registry Dose Dust Epithelial Epithelial Cells epithelial to mesenchymal transition Epithelium Erythroid exposure route Exposure to Fibrosis Functional disorder Gene Expression Gene Targeting Generations Goals Health high risk In Vitro in vivo Infiltration Inflammation Inflammatory Ingestion Inhalation Injury Intervention Iron Lung Lung diseases Lung Inflammation lung injury Maintenance Malignant Neoplasms Measures Mediating Metal exposure Metals Mining mitochondrial dysfunction Molecular Mus mutant Non-Malignant Nuclear Occupational Health Organ Organelles Outcome Oxidative Stress particle Particulate Pathway interactions Poison Population Intervention Populations at Risk Preventive Preventive treatment prophylactic protein aggregate Proteins Public Health Pulmonary Emphysema remediation Reporting Research Respiratory physiology response Risk Role Severities Side Site Soil Structure Sulforaphane superfund site Supplementation Tail Testing Therapeutic Tight Junctions Tissues Toxic effect transcription factor transcriptomics wasting |
