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| Systems-level genetic patterns underlying disseminated coccidioidomycosis in humans 项目
项目编号: 1R21AI152394-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: LUSSIER, YVES A.
  收藏 | 浏览/下载：5/0 | 提交时间：2021/08/12
Acute Address adverse outcome African American Alleles Automobile Driving Biochemical Biological Biological Process Biology bone Brain Candidate Disease Gene Caring Case Study Categories causal variant Chronic Clinical clinical care Coccidioides Coccidioidomycosis Code cohort Communicable Diseases Complex Data Databases desert fever design Disease Disease susceptibility DNA Emerging Communicable Diseases Equilibrium Exogenous Factors exome exome sequencing experience Filipino flu Foundations fungus Gene Expression Gene Mutation Genes Genetic genetic architecture Genetic Heterogeneity Genetic Predisposition to Disease genetic risk factor Genetic Variation genome-wide genome-wide analysis Genotype genotyped patients Guidelines Haplotypes Heterogeneity high risk HLA Antigens Human Human Genetics human leukocyte antigen testing IFNGR1 gene IL12RB1 gene Immune Immune response Immune system Immunocompetent Immunogenetics Immunological Models Immunosuppression Infection Inhalation insight Knowledge Life Lung Medical Modeling Molecular Mutation Mycoses National Institute of Allergy and Infectious Disease novel Organ Participant pathogen pathogen exposure Pathogenesis pathogenic fungus Pathology Pathway Analysis Pathway interactions Patients Pattern Phenotype Play Pneumonia Positioning Attribute Predisposition Proteins Quantitative Trait Loci rare variant Recommendation recruit Resistance Resources response Risk risk variant Role Sample Size Sampling Studies Signal Transduction Skin Soil STAT1 gene STAT3 gene Stimulus Symptoms System Systems Analysis Testing Therapeutic Time Variant whole genome |
| Understanding the natural Coccidioides bioaerosol in time and space and its relationship to disease 项目
项目编号: 1R21AI149660-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: ENGELTHALER, DAVID M
收藏 | 浏览/下载：6/0 | 提交时间：2021/08/12
Address Aerosols Affect Air air filter air sampling Animals Area beta diversity Biological Assay Canis familiaris Climate climate change Coccidioides Coccidioidomycosis Collection Communities Community Health Data desert fever Detection Development Disease disease natural history disorder risk DNA Dust Ecology Environment Environmental Monitoring Environmental Risk Factor Environmental Wind epidemiologic data Epidemiology Event exposed human population Exposure to Fungal DNA Fungal Spores fungus Genomics Health Health Care Costs healthcare community Human Human Activities Humidity Incidence Infection Inhalation Knowledge knowledge base Locales Location Meteorology metropolitan microbiome analysis Modeling Monitor Morbidity - disease rate Movement Multivariate Analysis mycobiome Nature novel strategies Outcome Particulate Matter pathogen pathogenic fungus Pattern Population Precipitation predictive modeling Prevalence process optimization prospective Public Health Recreation Research Research Personnel Risk Risk Factors risk mitigation Schools severe weather Site Soil Source Southwestern United States Spatial Distribution suburb System Temperature The science of Mycology Time Veterinarians Weather whole genome Work Workplace |
| Regulatory T cell function in predicting Valley fever outcomes 项目
项目编号: 1R21AI142261-01A1. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: HOYER, KATRINA K.
收藏 | 浏览/下载：16/0 | 提交时间：2021/08/12
Activities of Daily Living Acute acute infection adaptive immune response Adult Aftercare Age Algorithms Antibiotic Therapy Antifungal Agents Area Arizona Bacterial Infections base Biological Factors Biological Markers Blood California Case Study Cell physiology Cells Cessation of life Child Childhood Chronic Chronic Disease chronic infection Clinic Clinical Coccidioides Coccidioides immitis Coccidioides posadasii Coccidioidomycosis Contracts Data Data Set desert fever Detection Diagnosis Diagnostic Disease Disease Outcome Dust eosinophil Evaluation experience flu Frequencies fungus Health Immune Immune response Immunity Immunologic Factors Immunologic Markers Impaired health improved Incidence Infection Inhalation Knowledge Lung nodule Measurement Methods Mexico Modeling Monitor Mus neutrophil novel older patient Outcome pathogenic fungus Patient Care Patients pediatric patients peripheral blood Pharmaceutical Preparations Phenotype Population prediction algorithm Predictive Factor predictive modeling predictive test prevent Recurrent disease Regulatory T-Lymphocyte Relapse research study Resolution response Severities Severity of illness side effect Soil South America Southwestern United States Symptoms Testing Time tool Translational Research transmission process Travel Vaccines Washington Weather |
| Project 1 - Environmental Project 1 - EP1 - Immobilization of U, As, and Co-occurring Metals in Mine Wastes 项目
项目编号: 5P42ES025589-04. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: CERRATO, JOSE MANUEL
收藏 | 浏览/下载：4/0 | 提交时间：2021/08/12
Address Adsorption Aerobic Affect Amendment aqueous Basic Science bioaccumulation Biological Carbonates Characteristics Chemicals Chemistry Climate Climate Controls Collaborations Communities Complement contaminated drinking water cultural values Custom Decision Making Desert Climate Development Ecology Engineering Environment Environmental Engineering technology Environmental Microbiology experience experimental study Exposure to Exudate Geographic Factor Goals Hazardous Substances Hazardous Waste Sites Health Home environment Human IGFBP2 gene Immobilization In Vitro Individual Ingestion innovation inorganic phosphate interfacial Intervention iron oxide Knowledge Laboratories Ligands mathematical model Measures member metagenome Metal exposure metal poisoning Metals Methods microbiome microbiome alteration microorganism Microscopy migration Minerals Mining Modeling Molecular Native Americans Navajo New Mexico next generation sequencing Outcomes Research Oxides Pattern Phase Pilot Projects Plant Roots Plants Play Population Precipitation prevent Process programs Pueblo Race Rain Reaction remediation Research Resources Risk Risk Reduction Role Sampling Science Scientist Seasons Site Soil Source Spectrum Analysis Superfund Surface System Techniques Testing tool Toxic effect toxic metal tribal community tribal lands Tribes Underserved Population Universities uptake Uranium wasting Water water flow |
| Project 1 - Disruption of CpG island-mediated gene regulation and chromatin architecture in progeria and aging 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: BECK, SAMUEL
收藏 | 浏览/下载：5/0 | 提交时间：2021/08/12
Address Age of Onset age related Aging Architecture Atherosclerosis Biological Biology of Aging Biomedical Research Blindness Cardiac Myocytes Cell Differentiation process Cells Chromatin Chromosome Mapping Comparative Biology CpG Islands CRISPR/Cas technology Cytosine Data Set de novo mutation Defect Degenerative Disorder Dinucleoside Phosphates Disease DNA DNA Damage DNA Repair Economics Elements epigenetic regulation Euchromatin Fatty Liver Fluorescent in Situ Hybridization Frequencies Gene Expression Gene Expression Regulation Genes Genetic Genetic Transcription genome editing genome-wide Genomic Instability Goals Guanine Hair Hepatocyte Heterochromatin Impairment induced pluripotent stem cell innovation inorganic phosphate insight Lamin Type A Lamins Life Life Expectancy Link Mediating Meta-Analysis Modeling Molecular Morphology mRNA sequencing Musculoskeletal Mutation Natural regeneration Nuclear Nuclear Lamin Nuclear Lamina Pathology Patients Peripheral Physiological Predisposition prevent Process Progeria promoter Property Proteins Psyche structure Public Health Regulation Resources response restoration Skin Structural Protein Symptoms Testing therapy development tissue repair Tissues Undifferentiated |
| Comparative Functional Genomics (CFG) Core 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: GRABER, JOEL H
收藏 | 浏览/下载：1/0 | 提交时间：2021/08/12
Aging Animal Model Applications Grants Automation base Biological Biology Biomedical Research Cells Centers of Research Excellence chemotherapy Chemotherapy-induced peripheral neuropathy Clinic Collaborations Collection Communities comparative Comparative Biology Computer Analysis computerized tools Consultations Data Data Analyses Data Collection data management Data Set data sharing Databases design Development Education Educational Materials Ensure Epigenetic Process experience experimental analysis Experimental Designs Faculty Feedback Fees functional genomics Funding Generations Genetic Variation genome analysis genome-wide genomic data Genomics Goals Human Resources improved innovation interoperability Joints Lead Legal patent Mammals Medicine member MicroRNAs Modeling multiple data types Natural regeneration novel Organism Output Paper Patients Phase phosphoproteomics Play Procedures Process programs Proteomics Publications Quality Control regenerative Reproducibility Research Research Project Grants Research Support Resources RNA Role Scientist Services small molecule Software Engineering Standardization Students success System Systems Biology Testing theories tissue regeneration tissue repair tool Training Training Programs transcriptomics Untranslated RNA Update Whole Organism Yeasts |
| Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人: KHANNA, RAJESH
收藏 | 浏览/下载：14/0 | 提交时间：2021/08/12
Absence of pain sensation addiction Affect Afferent Neurons American Amitriptyline Analgesics analog Antidepressive Agents Arizona Axon Baclofen base Betulinic Acid Biological Assay biophysical properties Calcium Calcium Channel Blockers Calcium Channel Inhibition cancer pain Cancer Patient cancer survival cancer therapy Cell-Mediated Cytolysis Cells central sensitization chemotherapeutic agent chemotherapy Chemotherapy-induced peripheral neuropathy Chemotherapy-Oncologic Procedure Chronic chronic pain chronic pain relief chronic painful condition Clinical Clinical Trials Complex compliance behavior Complication counterscreen Coupled design dorsal horn Dose-Limiting drug discovery Drug Kinetics Drug Targeting duloxetine Dysesthesias effective therapy Effectiveness Esthesia Feeling Fiber G-Protein-Coupled Receptors Human improved In Vitro in vivo Indigenous inhibitor/antagonist Ion Channel Laboratories Lavandula Lead Malignant Neoplasms Mediating Mediator of activation protein Medical Medicinal Plants meetings Modeling Muscle relaxants Natural Products Neuraxis neuronal excitability Neurons Neuropathy neurotoxic neurotoxicity neurotransmission non-opioid analgesic Norepinephrine novel novel therapeutics Numbness Opiate Addiction Opioid opioid misuse Opioid Receptor opioid sparing opioid use Oral Paclitaxel Pain Pain management pain model pain relief pain signal painful neuropathy Paresthesia Pathogenesis Pathway interactions Peripheral Peripheral Nerves Peripheral Nervous System Peripheral Nervous System Diseases Pharmaceutical Preparations Pharmacology Pharmacotherapy Phase Plants Platinum Compounds preclinical study Prevalence Property Protein Isoforms Proteins Quality of life Rattus Regimen Regulation reuptake Role Safety screening Sensory sensory stimulus Serotonin Shock side effect Site small molecule somatosensory Southwestern United States Specificity Spinal Spinal Cord Spinal Ganglia Structure success Survival Rate synaptic function T-Type Calcium Channels taxane Testing Tissues Translating Treatment Protocols Universities venlafaxine Vinca Alkaloids voltage Work |
| Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis 项目
项目编号: 5R21CA205932-02. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-2020
负责人: BAKER, BILL J; CHAIN, PATRICK S. G.; MURRAY, ALISON ELIZABETH (contact)
收藏 | 浏览/下载：3/0 | 提交时间：2021/08/12
3-hydroxy-3-methylglutaryl-coenzyme A Anabolism Antarctic Architecture ascidian Atmosphere Bacteria Bacterial Genome base Base Sequence Bioinformatics cancer therapy candidate validation cell growth Cell Line cell type Cells chemotherapeutic agent chemotherapy Clinical Code contig Cytostatics cytotoxicity Data Development Diagnosis Disease drug development Drug Targeting fighting Gene Cluster Genes genetic manipulation Genome Genome Mappings genome sequencing Genomics Goals Harvest High-Risk Cancer Human Cell Line Hybrids Immunotherapy In Vitro indexing insight interest Ligase Macrolides Marines markov model Melanins melanocyte melanoma Melanoma Cell metagenome metagenomic sequencing Metastatic Melanoma microbial microbiome microorganism Mining Modeling Molecular Mutagenesis Natural Products New Agents next generation novel Organism Outcomes Research Pathway interactions peptide synthase Pharmaceutical Preparations Pharmacology polyketide synthase Preparation Procedures Production Proton Pump reference genome Research research and development Resistance Resistance development Ribosomal RNA Risk scale up screening Signal Transduction Pathway Skin Skin Cancer Source Specificity Specimen stratospheric ozone Structure Survival Rate symbiont System targeted agent Therapeutic tool Toxic effect Treatment Efficacy tumor Ultraviolet Rays United States vacuolar H+-ATPase whole genome |
| Project 1 - Environmental Project 1 - EP1 - Immobilization of U, As, and Co-occurring Metals in Mine Wastes 项目
项目编号: 5P42ES025589-02. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-
负责人: CERRATO, JOSE MANUEL
收藏 | 浏览/下载：3/0 | 提交时间：2021/08/12
Address Adsorption Aerobic Affect Amendment aqueous Basic Science bioaccumulation Biological Carbonates Characteristics Chemicals Chemistry Climate Climate Controls Collaborations Communities Complement contaminated drinking water cultural values Custom Decision Making Desert Climate Development Ecology Engineering Environment Environmental Engineering technology Environmental Microbiology experience experimental study Exposure to Exudate Geographic Factor Goals Hazardous Substances Hazardous Waste Sites Health Home environment Human IGFBP2 gene Immobilization In Vitro Individual Ingestion innovation inorganic phosphate interfacial Intervention Knowledge Laboratories Ligands mathematical model Measures member metagenome Metal exposure metal poisoning Metals Methods microbiome microbiome alteration microorganism Microscopy migration Minerals Mining Modeling Molecular Native Americans Navajo New Mexico next generation sequencing Outcomes Research Oxides Pattern Phase Pilot Projects Plant Roots Plants Play Population Precipitation prevent Process programs Pueblo Race Rain Reaction remediation Research Resources Risk Risk Reduction Role Sampling Science Scientist Seasons Site Soil Source Spectrum Analysis Superfund Surface System Techniques Testing tool Toxic effect toxic metal tribal community tribal lands Tribes Underserved Population Universities uptake Uranium wasting Water water flow |
| Data to Action: A Secondary School-based Citizen Science Project to Address Arsenic Contamination of Well Water 项目
项目编号: 3R25GM129796-02S1. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-2023
负责人: DISNEY, JANE ELIZABETH
收藏 | 浏览/下载：10/0 | 提交时间：2021/08/12
Address Arsenic base Biomedical Research career Centers for Disease Control and Prevention (U.S.) citizen science Committee Members Communication Communities Competence Computer software Data Data Analyses data portal data sharing drinking water Educational Curriculum Educational workshop Environmental Health Environmental Monitoring experience Future Teacher Generations Goals ground water hazard Health health data Home environment improved innovation Institutes Institution interest Knowledge Lead Learning Link literacy Maine Mathematics Measurable Medicine meetings Mentors Modeling Monitor Motivation Neighborhood Health Center New Hampshire novel Privatization Process programs Public Health recruit remediation Resources role model Rural School Teachers Schools Science science teacher Science, Technology, Engineering and Mathematics Education Scientific Inquiry Scientist Secondary Schools Services skills STEM career Students support network teacher teacher mentor Teacher Professional Development tool Training Translating water sampling water testing web site well water Work |
