干旱区生态环境知识资源中心(Arid): Structures and nucleic acid-binding preferences of the eukaryotic ARID domain

Arid

DOI	10.1515/hsz-2021-0404
	Structures and nucleic acid-binding preferences of the eukaryotic ARID domain
	Korn, Sophie Marianne; Schlundt, Andreas
通讯作者	Korn, SM ; Schlundt, A (corresponding author)，Goethe Univ Frankfurt, Inst Mol Biosci, Max von Laue Str 9, D-60438 Frankfurt, Germany. ; Korn, SM ; Schlundt, A (corresponding author)，Goethe Univ Frankfurt, Ctr Biomol Magnet Resonance BMRZ, Max von Laue Str 9, D-60438 Frankfurt, Germany.
来源期刊	BIOLOGICAL CHEMISTRY
ISSN	1431-6730
EISSN	1437-4315
出版年	2022-02
英文摘要	The DNA-binding AT-rich interactive domain (ARID) exists in a wide range of proteins throughout eukaryotic kingdoms. ARID domain-containing proteins are involved in manifold biological processes, such as transcriptional regulation, cell cycle control and chromatin remodeling. Their individual domain composition allows for a sub-classification within higher mammals. ARID is categorized as binder of double-stranded AT-rich DNA, while recent work has suggested ARIDs as capable of binding other DNA motifs and also recognizing RNA. Despite a broad variability on the primary sequence level, ARIDs show a highly conserved fold, which consists of six alpha-helices and two loop regions. Interestingly, this minimal core domain is often found extended by helices at the N- and/or C-terminus with potential roles in target specificity and, subsequently function. While high-resolution structural information from various types of ARIDs has accumulated over two decades now, there is limited access to ARID-DNA complex structures. We thus find ourselves left at the beginning of understanding ARID domain target specificities and the role of accompanying domains. Here, we systematically summarize ARID domain conservation and compare the various types with a focus on their structural differences and DNA-binding preferences, including the context of multiple other motifs within ARID domain containing proteins.
英文关键词	ARID containing proteins AT-rich interacting domain chromatin remodeling DNA-binding DNA-protein complex structural biology
类型	Review ; Early Access
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000751000900001
WOS关键词	RICH INTERACTION DOMAIN ; INTRINSICALLY DISORDERED REGIONS ; N-15 RESONANCE ASSIGNMENTS ; TRANSCRIPTION FACTOR ; DEAD RINGER ; FUNCTIONAL-ANALYSIS ; RNA RECOGNITION ; FAMILY PROTEINS ; CELL FATE ; DNA
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/377334
作者单位	[Korn, Sophie Marianne; Schlundt, Andreas] Goethe Univ Frankfurt, Inst Mol Biosci, Max von Laue Str 9, D-60438 Frankfurt, Germany; [Korn, Sophie Marianne; Schlundt, Andreas] Goethe Univ Frankfurt, Ctr Biomol Magnet Resonance BMRZ, Max von Laue Str 9, D-60438 Frankfurt, Germany
推荐引用方式 GB/T 7714	Korn, Sophie Marianne,Schlundt, Andreas. Structures and nucleic acid-binding preferences of the eukaryotic ARID domain[J],2022.
APA	Korn, Sophie Marianne,&Schlundt, Andreas.(2022).Structures and nucleic acid-binding preferences of the eukaryotic ARID domain.BIOLOGICAL CHEMISTRY.
MLA	Korn, Sophie Marianne,et al."Structures and nucleic acid-binding preferences of the eukaryotic ARID domain".BIOLOGICAL CHEMISTRY (2022).