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DOI | 10.1523/JNEUROSCI.3096-20.2021 |
Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture | |
Zotter, Brendan; Dagan, Or; Brady, Jacob; Baloui, Hasna; Samanta, Jayshree; Salzer, James L. | |
通讯作者 | Salzer, JL (corresponding author),NYU, Neurosci Inst, Dept Neurosci & Physiol, Langone Med Ctr, New York, NY 10016 USA. |
来源期刊 | JOURNAL OF NEUROSCIENCE |
ISSN | 0270-6474 |
EISSN | 1529-2401 |
出版年 | 2022 |
卷号 | 42期号:2页码:183-201 |
英文摘要 | Peripheral nerves are organized into discrete compartments. Axons, Schwann cells (SCs), and endoneurial fibroblasts (EFs) reside within the endoneurium and are surrounded by the perineurium, a cellular sheath comprised of layers of perineurial glia (PNG). SC secretion of Desert Hedgehog (Dhh) regulates this organization. In Dhh nulls, the perineurium is deficient and the endoneurium is subdivided into small compartments termed minifascicles. Human Dhh mutations cause a neuropathy with similar defects. Here we examine the role of Gli1, a canonical transcriptional effector of hedgehog signaling, in regulating peripheral nerve organization in mice of both genders. We identify PNG, EFs, and pericytes as Gli1-expressing cells by genetic fate mapping. Although expression of Dhh by SCs and Gli1 in target cells is coordinately regulated with myelination, Gli1 expression unexpectedly persists in Dhh null EFs. Thus, Gli1 is expressed in EFs noncanonically (i.e., independent of hedgehog signaling). Gli1 and Dhh also have nonredundant activities. Unlike Dhh nulls, Gli1 nulls have a normal perineurium. Like Dhh nulls, Gli1 nulls form minifascicles, which we show likely arise from EFs. Thus, Dhh and Gli1 are independent signals: Gli1 is dispensable for perineurial development but functions cooperatively with Dhh to drive normal endoneurial development. During development, Gli1 also regulates endoneurial extracellular matrix production, nerve vascular organization, and has modest, nonautonomous effects on SC sorting and myelination of axons. Finally, in adult nerves, induced deletion of Gli1 is sufficient to drive minifascicle formation. Thus, Gli1 regulates the development and is required to maintain the endoneurial architecture of peripheral nerves. |
英文关键词 | endoneurium Gli1 myelination perineurium peripheral nerve Schwann cell |
类型 | Article |
语种 | 英语 |
开放获取类型 | Green Submitted |
收录类别 | SCI-E |
WOS记录号 | WOS:000744037500003 |
WOS关键词 | DESERT-HEDGEHOG ; SCIATIC-NERVE ; ENDONEURIAL CHANGES ; GONADAL-DYSGENESIS ; PERINEURIAL GLIA ; PROTEIN TRACERS ; STEM-CELLS ; IN-VITRO ; EXPRESSION ; GROWTH |
WOS类目 | Neurosciences |
WOS研究方向 | Neurosciences & Neurology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/376568 |
作者单位 | [Zotter, Brendan; Dagan, Or; Brady, Jacob; Salzer, James L.] NYU, Neurosci Inst, Dept Neurosci & Physiol, Langone Med Ctr, New York, NY 10016 USA; [Baloui, Hasna] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden; [Baloui, Hasna] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden; [Samanta, Jayshree] Univ Wisconsin, Stem Cell & Regenerat Med Ctr, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53706 USA |
推荐引用方式 GB/T 7714 | Zotter, Brendan,Dagan, Or,Brady, Jacob,et al. Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture[J],2022,42(2):183-201. |
APA | Zotter, Brendan,Dagan, Or,Brady, Jacob,Baloui, Hasna,Samanta, Jayshree,&Salzer, James L..(2022).Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.JOURNAL OF NEUROSCIENCE,42(2),183-201. |
MLA | Zotter, Brendan,et al."Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture".JOURNAL OF NEUROSCIENCE 42.2(2022):183-201. |
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