干旱区生态环境知识资源中心(Arid): Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells

Arid

DOI	10.1016/j.ynstr.2021.100397
	Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells
	Bartlett, A. A.; DeRosa, H.; Clark, M.; Lapp, H. E.; Guffanti, G.; Hunter, R. G.
通讯作者	Bartlett, AA (corresponding author), Univ Massachusetts, 100 Morrissey Blvd, Boston, MA 02125 USA.
来源期刊	NEUROBIOLOGY OF STRESS
ISSN	2352-2895
出版年	2021
卷号	15
英文摘要	The hippocampus is a highly plastic brain region sensitive to environmental stress. It shows dynamic changes in epigenetic marks associated with stress related learning. Previous work has shown that acute stress induces substantial transient changes in histone H3 lysine 9 trimethylation (H3K9me3). Moreover, increased H3K9me3 is enriched in hippocampal gene deserts accumulating within endogenous retroviruses and transposable elements. We have found that in response to acute glucocorticoid treatment, a similar change in global H3K9me3 is observed. However, when localized we found that H3K9me3 is markedly decreased at B2 short interspersed nuclear elements but not within intracisternal-A particle endogenous retroviruses. Further, decreased H3K9me3 valence within B2 elements was associated with increased transcript abundance. These data demonstrate the capacity for acute glucocorticoids to mobilize transposable elements via epigenetic unmasking. Reconciled with previous findings following acute stress, this suggests the capacity for mobile elements to potentially function as novel regulators given their dynamic regulation by stress and glucocorticoids.
英文关键词	Glucocorticoid Epigenetic Transposon B2 SINE lncRNA Histone modification Chromatin
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000709585700004
WOS关键词	RNA-POLYMERASE-II ; B2 RNA ; REPRESS TRANSCRIPTION ; TRANSPOSABLE ELEMENTS ; RESPONSE ELEMENTS ; HEAT-SHOCK ; STRESS ; GENOME ; RECEPTOR
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/368230
作者单位	[Bartlett, A. A.; DeRosa, H.; Clark, M.; Lapp, H. E.; Hunter, R. G.] Univ Massachusetts, 100 Morrissey Blvd, Boston, MA 02125 USA; [Bartlett, A. A.; Guffanti, G.] Harvard Med Sch, McLean Hosp, 115 Mill St, Belmont, MA 02478 USA
推荐引用方式 GB/T 7714	Bartlett, A. A.,DeRosa, H.,Clark, M.,et al. Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells[J],2021,15.
APA	Bartlett, A. A.,DeRosa, H.,Clark, M.,Lapp, H. E.,Guffanti, G.,&Hunter, R. G..(2021).Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells.NEUROBIOLOGY OF STRESS,15.
MLA	Bartlett, A. A.,et al."Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells".NEUROBIOLOGY OF STRESS 15(2021).