干旱区生态环境知识资源中心(Arid): Which skin prick test wheal size detects true allergy to Salsola kali?

Arid

DOI	10.23822/EurAnnACI.1764-1489.161
	Which skin prick test wheal size detects true allergy to Salsola kali?
	Al-Ahmad, M.; Jusufovic, E.; Arifhodzic, N.
通讯作者	Al-Ahmad, M (corresponding author), Kuwait Univ, Fac Med, Dept Microbiol, Kuwait 13110, Kuwait.
来源期刊	EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY
ISSN	1764-1489
出版年	2021
卷号	53 期号:5 页码:228-233
英文摘要	Background. Sensitization to Salsola kali (Sk) weed pollen allergen is the most common cause of seasonal allergic rhinitis (SAR) in Middle East countries. Aim. To identify Salsola kali skin prick test (SkSPT) wheal size cut-off, able to determine true allergy among adult patients with moderate to severe SAR, who are in need of Salsola kali allergen specific immunotherapy (SkAIT). Methods. In 151 adults with moderate to severe SAR, mean age 32.79 +/- 10.79 years, of both gender (females: 43.05%), with a positive SkSPT, (i.e., cut off wheal longest diameter of 3 mm) and one or more other local weed pollens, Salsola kali nasal provocation test (SkNPT) was carried out. Response was assessed both subjectively, with scores, and objectively, by measuring peak nasal inspiratory flow (PNIF). Safety profile of SkNPT was assessed using peak expiratory flow rate (PEF) measurements. Results. SkNPT positive response was found in 125 patients (82.78%). Mean skin prick test (SPT) wheal size to Sk was bigger in the nasal provocatin test (NPT) positive group (9 mm) compared to the NPT negative patients (5 mm), p < 0.0001. ROC analysis showed that a SPT wheal size to Sk at the threshold of > 7.5 mm enabled identification of SkNPT positivity with a sensitivity of 73.6% and specificity of 100.0% (area under the curve 0.9498, standard error 0.01808; 95% confidence interval (CI): 0.9144 to 0.9853; p < 0.0001). Conclusions. SPT wheal size of 3 mm might overestimate the presence of real allergy to Sk in a desert environment. A SPT wheal size > 7.5 mm for Sk appears to distinguish individuals who develop disease from those who does not. Physicians should select the proper SPT wheal size value as an appropriate criterion according to the allergen than using a uniform cut off value in patients eligible for SkAIT. Impact statement A SPT wheal size > 7.5 mm for Salsola kali appears to distinguish individuals who develop seasonal allergic rhinitis from those who does not, with a sensitivity of 73.6% and specificity of 100.0%.
英文关键词	Salsola kali skin prick test nasal provocation test allergy sensitivity specificity
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	ESCI
WOS记录号	WOS:000695420800006
WOS关键词	NASAL PROVOCATION ; IMMUNOGLOBULIN-E ; RHINITIS ; POLLEN ; ATOPY
WOS类目	Allergy
WOS研究方向	Allergy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363204
作者单位	[Al-Ahmad, M.; Arifhodzic, N.] Al Rashed Allergy Ctr, Kuwait, Kuwait; [Al-Ahmad, M.] Kuwait Univ, Fac Med, Dept Microbiol, Kuwait 13110, Kuwait; [Jusufovic, E.] Univ Tuzla, Fac Med, Tuzla, Bosnia & Herceg
推荐引用方式 GB/T 7714	Al-Ahmad, M.,Jusufovic, E.,Arifhodzic, N.. Which skin prick test wheal size detects true allergy to Salsola kali?[J],2021,53(5):228-233.
APA	Al-Ahmad, M.,Jusufovic, E.,&Arifhodzic, N..(2021).Which skin prick test wheal size detects true allergy to Salsola kali?.EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY,53(5),228-233.
MLA	Al-Ahmad, M.,et al."Which skin prick test wheal size detects true allergy to Salsola kali?".EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY 53.5(2021):228-233.