干旱区生态环境知识资源中心(Arid): Palaeopathology and amino acid delta C-13 analysis: Investigating pre-Columbian individuals with tuberculosis at Pica 8, northern Chile (1050-500 BP)

Arid

DOI	10.1016/j.jas.2021.105367
	Palaeopathology and amino acid delta C-13 analysis: Investigating pre-Columbian individuals with tuberculosis at Pica 8, northern Chile (1050-500 BP)
	Mora, Alice; Pacheco, Aryel; Roberts, Charlotte A.; Smith, Colin
通讯作者	Mora, A (corresponding author), La Trobe Univ, Dept Archaeol & Hist, Bundoora, Vic 3086, Australia.
来源期刊	JOURNAL OF ARCHAEOLOGICAL SCIENCE
ISSN	0305-4403
EISSN	1095-9238
出版年	2021
卷号	129
英文摘要	Bulk delta N-15 and delta C-13 values of proteinaceous tissues are being increasingly used in bioarchaeological studies to elucidate the physio-pathological status of ancient individuals. This method has not always been successful. The present study aims to explore the novel use of single amino acid carbon isotope analysis in palaeopathology by investigating the effect of a serious infectious disease, tuberculosis (TB), on the isotope composition of two collagenous tissues (tendon, rib). This is achieved by comparing the bulk and amino acid stable isotope compositions of collagenous tissues collected from human remains with and without TB-like bone lesions. The sample set comprises twelve adult individuals (males = 6, females = 6), who were buried at Pica 8, an inland oasis situated on the mid-elevation plains of northern Chile (Late Intermediate Period, similar to 1050-500 BP). Similarity and consistency in the diet of these individuals are explored using amino acid carbon isotope analysis of 1-cm hair segments longitudinally cut along a single hair fibre. The results show that there is a difference between collagen delta C-13 serine values measured in the rib collagen of five individuals presenting TB-like bone lesions (3 males and 2 females) and in those five without lesions (3 males and 2 females; control individuals). The rib collagen delta C-13 serine values of pathological individuals are lower (more negative) than those of the control individuals. Within the group of pathological individuals, lower delta C-13 serine values in rib collagen are correlated with higher (more positive) delta N-15 values. Since only individuals (N = 10) with similar dietary intakes were included in the statistical analyses, it appears that the delta C-13 serine values could be linked to altered carbon metabolism, rather than induced by dietary factors. Serine accounts for less than 3% of the total carbon in bone collagen, and thus an altered serine metabolism would be masked within the averaged bulk carbon isotope value. In future studies, it is advised to undertake stable carbon isotope analysis of non-essential amino acids as a means of characterising pathologically altered body tissues.
英文关键词	Stable isotope Amino acid metabolism Serine Pathology Mycobacterium tuberculosis South America
类型	Article
语种	英语
收录类别	SCI-E ; SSCI ; AHCI
WOS记录号	WOS:000646199700002
WOS关键词	NITROGEN ISOTOPE RATIOS ; ONE-CARBON METABOLISM ; BONE-COLLAGEN ; STABLE CARBON ; MYCOBACTERIUM-TUBERCULOSIS ; DIETARY RECONSTRUCTION ; MANAGEMENT-PRACTICES ; ATACAMA DESERT ; RIB LESIONS ; FOOD-WEB
WOS类目	Anthropology ; Archaeology ; Geosciences, Multidisciplinary
WOS研究方向	Anthropology ; Archaeology ; Geology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350667
作者单位	[Mora, Alice; Smith, Colin] La Trobe Univ, Dept Archaeol & Hist, Bundoora, Vic 3086, Australia; [Pacheco, Aryel; Roberts, Charlotte A.] Univ Durham, Dept Archaeol, Durham DH1 3LE, England; [Smith, Colin] Univ Burgos, Lab Evoluc Humana, Dept Hist Geog & Comunicac, Burgos 09001, Spain
推荐引用方式 GB/T 7714	Mora, Alice,Pacheco, Aryel,Roberts, Charlotte A.,et al. Palaeopathology and amino acid delta C-13 analysis: Investigating pre-Columbian individuals with tuberculosis at Pica 8, northern Chile (1050-500 BP)[J],2021,129.
APA	Mora, Alice,Pacheco, Aryel,Roberts, Charlotte A.,&Smith, Colin.(2021).Palaeopathology and amino acid delta C-13 analysis: Investigating pre-Columbian individuals with tuberculosis at Pica 8, northern Chile (1050-500 BP).JOURNAL OF ARCHAEOLOGICAL SCIENCE,129.
MLA	Mora, Alice,et al."Palaeopathology and amino acid delta C-13 analysis: Investigating pre-Columbian individuals with tuberculosis at Pica 8, northern Chile (1050-500 BP)".JOURNAL OF ARCHAEOLOGICAL SCIENCE 129(2021).