干旱区生态环境知识资源中心(Arid): Radiation for persistent or recurrent epithelial ovarian cancer: a need for reassessment

Arid

DOI	10.3857/roj.2017.00213
	Radiation for persistent or recurrent epithelial ovarian cancer: a need for reassessment
	Choi, Noorie; Chang, Ji Hyun; Kim, Suzy; Kim, Hak Jae
通讯作者	Chang, JH
来源期刊	RADIATION ONCOLOGY JOURNAL
ISSN	2234-3156
出版年	2017
卷号	35 期号:2 页码:144-152
英文摘要	Purpose: The role of radiotherapy (RT) was largely deserted after the introduction of platinum-based chemotherapy, but still survival rates are disappointingly low. This study focuses on assessing the clinical efficacy of RT in relation to chemotherapy resistance. Materials and Methods: From October 2002 to January 2015, 44 patients were diagnosed with epithelial ovarian cancer (EOC) and treated with palliative RT for persistent or recurrent EOC. All patients received initial treatment with optimal debulking surgery and adjuvant platinum-based chemotherapy. The biologically effective dose (BED) was calculated with alpha/beta set at 10. Ninety-four sites were treated with RT with a median BED of 50.7 Gy (range 28.0 to 79.2 Gy). The primary end-point was the in-field local control (LC) interval, defined as the time interval from the date RT was completed to the date any progressive or newly recurring disease within the RT field was detected on radiographic imaging. Results: The median follow-up duration was 52.3 months (range 7.7 to 179.0 months). The 1-year and 2-year in-field LC rates were 66.0% and 55.0%, respectively. Comparisons of percent change of in-field tumor response showed similar distribution of responses among chemoresistant and chemosensitive tumors. On multivariate analysis of predictive factors for in-field LC analyzed by sites treated, BED >= 50 Gy (hazard ratio, 0.4; confidence interval, 0.2-0.9; p = 0.025) showed better outcomes. Conclusion: Regardless of resistance to platinum-based chemotherapy, RT can be a feasible treatment modality for patients with persistent of recurrent EOC. The specific role of RT using updated approaches needs to be reassessed.
英文关键词	Ovarian neoplasms Palliative treatment Radiotherapy
类型	Article
语种	英语
开放获取类型	Green Published, Bronze
收录类别	ESCI
WOS记录号	WOS:000406508300006
WOS关键词	ADJUVANT RADIOTHERAPY ; CLEAR-CELL ; THERAPY ; SURVIVAL ; CHEMOTHERAPY ; MANAGEMENT ; IRRADIATION ; CARCINOMA ; CLASSIFICATION ; CONSOLIDATION
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/332197
作者单位	[Choi, Noorie; Kim, Hak Jae] Seoul Natl Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea; [Chang, Ji Hyun; Kim, Suzy] SMG SNU Boramae Med Ctr, Dept Radiat Oncol, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea
推荐引用方式 GB/T 7714	Choi, Noorie,Chang, Ji Hyun,Kim, Suzy,et al. Radiation for persistent or recurrent epithelial ovarian cancer: a need for reassessment[J],2017,35(2):144-152.
APA	Choi, Noorie,Chang, Ji Hyun,Kim, Suzy,&Kim, Hak Jae.(2017).Radiation for persistent or recurrent epithelial ovarian cancer: a need for reassessment.RADIATION ONCOLOGY JOURNAL,35(2),144-152.
MLA	Choi, Noorie,et al."Radiation for persistent or recurrent epithelial ovarian cancer: a need for reassessment".RADIATION ONCOLOGY JOURNAL 35.2(2017):144-152.