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Hyperspectral image possesses incomparable advantage over spaceborne multispectral image when it is employed to quantitatively retrieve these parameters such as vegetation type, coverage, biomass, bare soil moisture, etc. This paper focuses on crucial issues present in the pre-processing of hyperspectral image: band selection, edge radiant correction, tangent correction and spectral reflectivity conversion, exemplified by a case study in which modular airborne OMIS-I imaging spectrometer data are employed to evaluate desertification. The author gives comprehensive consideration to the statistic characteristics of each spectral band, diagnostic spectral reflection of different targets and the purpose of practical application, and fixed upon 41 applicable bands after trying different bands. In the course of edge radiant correction, one correction method based on histogram matching was used, and its result was satisfactory. In addition, tangent correction directing against tangent distortion was carried out, which enriched the normal geometric rectification. Lastly, during the process of surface feature spectral reflectivity conversion, the author converted symbolic model into statistic model by employing some necessary theoretical inference and parameter-setting. The result suggests the quality of OMIS-I data get better improved after these processing and basically can meet the requirements of quantitative retrieval for desertification evaluation.